Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection.
نویسندگان
چکیده
Hyperimmune globulins were reported to prevent and treat fetal cytomegalovirus (CMV) infection during pregnancy. Here, we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titers and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to fetuses. Preliminary data on perinatal outcomes of the first 67 newborns are encouraging.
منابع مشابه
Prophylactic intravenous immunoglobulin injections to mothers with primary cytomegalovirus infection.
The aim of this trial study was to assess the preventive efficacy of immunoglobulin with a high titer of anti-CMV antibody for mother-to-fetus cytomegalovirus (CMV) transmission among pregnant women with primary/acute CMV infection. The primary CMV infection in mothers was diagnosed by a positive test for CMV IgM and/or low IgG avidity. Intact type immunoglobulin with a high titer of anti-CMV a...
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Background and purpose: Primary cytomegalovirus (CMV) infection occurs in 0.15-2.0% of all pregnancies and might causes abortion. Actually CMV infections are most common in females and rate of infection increases with age. In pregnant women it usually occurs in ages below 30 years old. Aim of the present study was investigating on the seropositivity rate of CMV in pregnant women to determine th...
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ورودعنوان ژورنال:
- Clinical and vaccine immunology : CVI
دوره 19 12 شماره
صفحات -
تاریخ انتشار 2012